Protease

Protease molecular structure

1-2 year old toddlersSkin contact product

Check for Different Age (6 available)

Is this toddler-safe to use Protease?

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USE WITH CAUTION
Danger Score: 5 (Lower is safer)
Quick Answer: Protease use with caution for 1-2 year old toddlers when used in topical products. Watch for toddler-specific sensitivities.

ℹ️General Overview

Protease is an enzyme that is usually low risk for general health, but it can cause allergic skin or immune reactions in some people. For toddlers (1–2 years old), there is a moderate chance of irritation or allergy, so be careful.

What to Do

If you see “protease” or similar names on a product label, consider choosing a different product without enzymes for your toddler. If you try a product that contains protease, do a small patch test on a non-sensitive area first and wait 24–48 hours. Use it only on normal, unbroken skin, not on cuts or rashes. Stop use right away if you see redness, hives, swelling, itching, or any breathing difficulty and seek medical help for serious reactions.

⚠️Warnings

Do not use products containing protease on toddlers with eczema, known skin allergies, or asthma without talking to your pediatrician first. Peer‑reviewed studies show strong evidence that protease can act as a human allergen, and some product verification programs restrict its use unless manufacturers provide clear safety data. Watch for skin redness, rash, itching, swelling, or breathing problems after exposure.

Confidence: MEDIUM

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Safety Risk Labels

This ingredient has the following documented risks:

Immune system: Peer-reviewed studies show this protease acts as a human allergen and can trigger immune reactions. That means some people — including children with sensitive skin — could have allergic responses after using products that contain it.
Irritant: Because the ingredient can cause allergic reactions in people, it can also lead to skin redness, itching, or rashes when applied to the skin. This risk is supported by peer-reviewed literature reporting strong evidence of human allergen effects.
Eczema: Allergic or immune reactions to this protease can trigger or make eczema and similar skin conditions worse. Peer-reviewed sources note strong allergen evidence, which makes flare-ups more likely for children with eczema-prone skin.

Tap or hover over labels to see detailed risk information.

Alternative Names for Protease

This ingredient may also be listed as:

proteasePROTEASEBACILLUS SUBTILIS NEUTRAL PROTEASEA.S. 1.398BACTERIAL PROTEASE

Always check ingredient labels carefully, as ingredients may be listed under different names.

Common Questions About Protease

Is this toddler-safe to use Protease?

Use caution with Protease for 1-2 year old toddlers. Some safety concerns have been identified.

What are the immune system risks of Protease for toddlers?

Could weaken or confuse immune system. Young children may be more sensitive to these effects.

What are the irritant risks of Protease for toddlers?

Can cause skin redness, itchiness, or rashes—especially on sensitive baby skin. Young children may be more sensitive to these effects.

What are the eczema risks of Protease for toddlers?

Linked to triggering or worsening eczema and similar skin conditions. Young children may be more sensitive to these effects.

What products contain Protease?

Protease is commonly found in skincare products, cosmetics, and topical applications. Always check ingredient labels before use.

When can toddlers using products with Protease?

The appropriate age depends on the specific ingredient properties and concentration. This analysis is for 1-2 year old toddlers. Use the age selector above to check other ages.

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