Papain

Papain molecular structure

6-12 month old babiesSkin contact product

Check for Different Age (6 available)

Can older babies use Papain?

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NOT RECOMMENDED
Danger Score: 6 (Lower is safer)
Quick Answer: Papain not recommended for 6-12 month old babies when used in topical products. Monitor for any reactions in older babies.

ℹ️General Overview

For babies 6–12 months (infants), papain can irritate the skin, eyes, or lungs and can cause allergic reactions in some people. Because babies’ skin is still sensitive, I recommend being cautious with products that contain papain.

What to Do

Avoid using products with papain on baby’s face, around the eyes, mouth, or on broken or red skin. Prefer products that rinse off rather than leave-on exfoliants. If you must use a product with papain, do a small patch test on the baby’s arm and wait 24–48 hours before wider use. Do not use powdered or spray forms near the baby’s face to avoid breathing it in. Read ingredient lists for alternate names (papain, papaine, papainase, vegetable pepsin). If you see any redness, swelling, rash, coughing or breathing trouble, stop use and contact your pediatrician.

⚠️Warnings

Primary concerns come from hazard classifications and health reports: it is labeled an eye, skin and lung irritant (EU GHS Hazard Labeling Codes) and there is evidence it can cause respiratory or immune reactions in people (Association of Occupational and Environmental Clinics and medical literature). Some product verification programs restrict its use unless safety is shown. Also, official food authorities note it may be used in limited, specific food applications (FDA), but that does not mean it is automatically safe for delicate infant skin. Watch for: immediate redness, swelling, hives, persistent crying, wheeze or difficulty breathing. If any of these occur, stop use and seek medical help.

Confidence: HIGH

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Safety Risk Labels

This ingredient has the following documented risks:

Irritant: Papain is classified under EU GHS hazard codes as an irritant to skin, eyes, and lungs, and the ingredient record flags a high concern for irritation. This means it can cause skin redness, stinging or rashes, watery or sore eyes, and breathing irritation on contact.
Immune system: There is moderate evidence that papain can trigger immune or allergic reactions. A review in the U.S. National Library of Medicine notes immune/ allergy concerns, and occupational health experts (AOEC) report strong evidence that papain can act as a human immune and respiratory allergen. This can cause hives, swelling, or other allergic responses in some people.
Asthma: Papain is identified as a respiratory toxicant/allergen and is listed as a lung irritant by occupational health sources and EU GHS. Because of this, it can worsen breathing problems or trigger asthma attacks in sensitive children.
Environmental: An environmental agency (Environment Canada) lists papain as an uncertain environmental toxin. That means its effects on wildlife or ecosystems are not well known and could be harmful, so there is an environmental concern.

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Alternative Names for Papain

This ingredient may also be listed as:

papainVERMIZYMVELARDONVEGETABLE PEPSINSUMMETRINNEMATOLYTCAROIDARBUZPAPAINEPAPAINASEPAPAIN

Always check ingredient labels carefully, as ingredients may be listed under different names.

Common Questions About Papain

Can older babies safely use Papain?

Papain is not recommended for 6-12 month old babies due to potential safety risks.

What are the irritant risks of Papain for older babies?

Can cause skin redness, itchiness, or rashes—especially on sensitive baby skin. This is especially important for babies whose skin and systems are still developing.

What are the immune system risks of Papain for older babies?

Could weaken or confuse immune system. This is especially important for babies whose skin and systems are still developing.

What are the asthma risks of Papain for older babies?

Can make breathing issues like asthma worse in babies and kids. This is especially important for babies whose skin and systems are still developing.

What are the environmental risks of Papain for older babies?

Possible negative effects on the environment This is especially important for babies whose skin and systems are still developing.

What products contain Papain?

Papain is commonly found in skincare products, cosmetics, and topical applications. Always check ingredient labels before use.

Is this appropriate for older babies to using products with Papain?

The appropriate age depends on the specific ingredient properties and concentration. This analysis is for 6-12 month old babies. Use the age selector above to check other ages.

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