Poloxamer 407

adultsSkin contact product

Check for Different Age (6 available)

Is this safe for adults to use Poloxamer 407?

YES - Generally Safe
Danger Score: 1 (Lower is safer)
Quick Answer: Poloxamer 407 is generally considered safe for adults when used in topical products. Adults generally have higher tolerance.

ℹ️General Overview

For adults, Poloxamer 407 (used in creams and gels) is usually low risk when used on normal skin in regular amounts. It’s unlikely to cause cancer, allergies, or effects on having children based on available information.

What to Do

Use products that list the ingredient at normal concentrations and follow the product directions. Do a small patch test on a forearm if you have sensitive skin. Avoid using lots of a product containing this ingredient every day over very large areas or under tight dressings for long periods. If pregnant, breastfeeding, or treating broken or inflamed skin, check with your doctor before regular use.

⚠️Warnings

Watch for any skin irritation or allergic reaction; stop use if redness, itching, or rash appears. Some government reviewers (Environment Canada) have raised concerns about environmental persistence and possible effects on organs, and industry safety reviews (Cosmetic Ingredient Review) note data gaps and limits on safe concentrations or impurities—so prefer products from reputable brands that disclose safety testing. Also note some product-verification programs restrict use of this ingredient unless manufacturers provide safety substantiation (source: Cosmetic Ingredient Review, Environment Canada).

Confidence: MEDIUM

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Safety Risk Labels

This ingredient has the following documented risks:

Organ Risk: Environment Canada reviewed this ingredient and flagged it as likely to be toxic or harmful to non-reproductive organs and gave it a medium human-health priority. That means repeated or large exposures could harm organs like the liver or kidneys, according to that assessment.
Builds Up: Environment Canada identified this substance as persistent and potentially bioaccumulative with a moderate-to-high toxicity concern. Persistent and bioaccumulative substances can collect in the body over time with repeated use, which raises long‑term exposure worries.
Environmental: An environmental review found this ingredient is suspected to be an environmental toxin and raised ecotoxicology concerns. This means it may harm wildlife or persist in the environment after use.
Long-Term Risk: Because regulators have noted persistence, possible buildup, and organ toxicity potential, there is a plausible link to longer-term health effects from repeated exposure. The cosmetic safety review also notes data gaps, so long-term effects are not fully ruled out.

Tap or hover over labels to see detailed risk information.

Alternative Names for Poloxamer 407

This ingredient may also be listed as:

poloxamer 407UNII-52901V8XARPROPYLENE OXIDE ETHYLENE OXIDE75-H-1400OXIRANE, POLYMER WITH OXIRANE.ALPHA.-HYDRO-.OMEGA.-HYDROXYPOLY(OXYETHYLENE)POLY(OXYPROPYLENE)POLY(OXYETHYLENE) BLOCK COPOLYMERALPHA-HYDRO-OMEGA-HYDROXYPOLY(OXYETHYLENE)A-POLY(OXOPROPYLENE)B-POLY(OXYETHYLENE)A BLOCK COPOLYMERADEKA PLURONIC F-108ETHYLENE OXIDE PROPYLENE OXIDE199SZS8E2QTSL 431

Always check ingredient labels carefully, as ingredients may be listed under different names.

Common Questions About Poloxamer 407

Is this safe for adults to use Poloxamer 407?

Yes, Poloxamer 407 is generally considered safe for adults based on current research.

What are the organ risk risks of Poloxamer 407 for adults?

May harm organs like liver, kidneys, or lungs with repeated use.

What are the builds up risks of Poloxamer 407 for adults?

Builds up in the body over time with repeated use.

What are the environmental risks of Poloxamer 407 for adults?

Possible negative effects on the environment

What are the long-term risk risks of Poloxamer 407 for adults?

Linked to long-term health effects after years of use or exposure.

What products contain Poloxamer 407?

Poloxamer 407 is commonly found in skincare products, cosmetics, and topical applications. Always check ingredient labels before use.

When can adults using products with Poloxamer 407?

The appropriate age depends on the specific ingredient properties and concentration. This analysis is for adults. Use the age selector above to check other ages.

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