For adults, Poloxamer 407 (used in creams and gels) is usually low risk when used on normal skin in regular amounts. It’s unlikely to cause cancer, allergies, or effects on having children based on available information.
Use products that list the ingredient at normal concentrations and follow the product directions. Do a small patch test on a forearm if you have sensitive skin. Avoid using lots of a product containing this ingredient every day over very large areas or under tight dressings for long periods. If pregnant, breastfeeding, or treating broken or inflamed skin, check with your doctor before regular use.
Watch for any skin irritation or allergic reaction; stop use if redness, itching, or rash appears. Some government reviewers (Environment Canada) have raised concerns about environmental persistence and possible effects on organs, and industry safety reviews (Cosmetic Ingredient Review) note data gaps and limits on safe concentrations or impurities—so prefer products from reputable brands that disclose safety testing. Also note some product-verification programs restrict use of this ingredient unless manufacturers provide safety substantiation (source: Cosmetic Ingredient Review, Environment Canada).
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Scientific research related to this ingredient:
These research articles provide scientific evidence about Poloxamer 407 safety and effects.
Yes, Poloxamer 407 is generally considered safe for adults based on current research.
May harm organs like liver, kidneys, or lungs with repeated use.
Builds up in the body over time with repeated use.
Possible negative effects on the environment
Linked to long-term health effects after years of use or exposure.
Poloxamer 407 is commonly found in skincare products, cosmetics, and topical applications. Always check ingredient labels before use.
The appropriate age depends on the specific ingredient properties and concentration. This analysis is for adults. Use the age selector above to check other ages.
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